Cyanobacterial blooms among the worst yet intensifying environmental hazards in human history, in terms of duration, scale, and damage. Appearing in as early as 1880s in eutrophic freshwaters in the recorded history caused by human activities, CHABs have now expanded to a global scale, in all freshwater, brackish, and marine waters. CHABs result from synergism between elevated nutrients and superior ecophysiology of blooming cyanobacteria. Although the driving roles of elevated nutrients have been established in a consensus, the common ecophysiology of CHABs has been little understood. Here we manually reconstructed the metabolic pathways ecologically inferred to be associated with cyanobacterial blooms in literature